Wednesday, December 7, 2011

Top-grade stem cells seen boosting research trials (Reuters)

LONDON (Reuters) ? British scientists have made the first human embryonic stem cells of a high enough grade to use in patients and deposited them in a public stem cell bank for development in human trials by drug companies and researchers by 2014.

A team from King's College London said on Monday they were submitting two clinical-grade stem cell lines to the UK Stem Cell Bank (UKSBC), which will test and validate them before offering them to researchers.

This could speed the path towards new stem-cell treatments for conditions like blindness, severe injury or heart disease.

"This first batch of cells is the culmination of nearly 10 years of research. This is a significant milestone," said Peter Braude, who led the King's team.

The cells are the first to be grown completely free from animal-derived products, known as "xeno-free," and developed specifically to be of clinical grade and for public use.

The hope is that the cells will be grown and processed by the bank to feed cell stocks for human trials and, beyond that, patient treatments.

The cells have the potential to become the "gold standard" lines for developing new stem cell based therapies for use in regenerative medicine trials in patients, Braude told reporters at a briefing.

It is likely to be many years before treatments are fully developed and licensed, but the cells could be used in human trials of potential therapies by 2014, the team said.

Stem cells are the body's master cells, the source for all other cells. Scientists say they could transform medicine, providing treatments for blindness, spinal cord and other severe injuries, as well as generating cells for damaged organs.

Human embryonic stem (hES) cells can be grown in the laboratory indefinitely while retaining their capacity to develop into specialized cell types, such as nerve or heart muscle cells, which can then be used in clinical trials.

The UK Stem Cell bank already has more than 90 research grade stem cell lines for use in laboratory studies, but as yet has no clinical grade xeno-free lines for use in human trials.

"In the future, patients hoping for the benefit of regenerative medicine for serious medical conditions caused by illness, injury and ageing can expect improved progress on cures or amelioration from hES cell-based therapy," said Dusko Ilic, a senior lecturer in stem cell science at King's.

A few companies, such as Pfizer and Advanced Cell Technology, are already conducting or are about to start human trials using hES cells -- which are harvested from embryos -- to test their potential for repairing spinal cord injuries and eye disorders like macular degeneration.

But the hES cell lines for these early trials were reclassified from "research grade" to "clinical grade" for specific short-term clinical studies in selected disease areas.

Braude said this is not considered appropriate for the future of cell therapy because of the expense of extra testing and reclassification, and the potential risks.

"While it might be reasonable to incur additional risks for these early pioneering studies, it is not reasonable to accept these risks for the long-term future," he said. "Therefore the highest standard of xeno-free lines are urgently needed."

Braude's team's cells were grown from frozen embryos donated by patients who had had in-vitro fertilization (IVF) treatment and no longer wanted to use their remaining stored embryos. The embryos would otherwise have been discarded, Braude said.

Glyn Stacey, head of the UKSCB, said these first clinical grade lines would be an "important resource" and an initial step towards the bank's aim to make available a panel of tested clinical grade lines within the next three years.

"The process of testing will be rigorous and not all cells lines received will make the grade," he said.

(Editing by David Cowell)

Source: http://us.rd.yahoo.com/dailynews/rss/biotech/*http%3A//news.yahoo.com/s/nm/20111206/hl_nm/us_britain_stemcells

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Tuesday, December 6, 2011

Video: December's best iPad apps for kids

Source: http://www.msnbc.msn.com/id/42218772/vp/45499464#45499464

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Monday, December 5, 2011

Congo's Kabila leading in early results (AP)

KINSHASA, Congo ? Preliminary results from Congo's presidential election show incumbent Joseph Kabila leading opposition leader Etienne Tshisekedi, although the country's election chief warned only a small percentage of precincts had been counted.

With around 15 percent of votes tallied, Kabila leads with over 1,52 million, around 52 percent, according to results announced Friday. Tshisekedi is second among the 11 candidates with 997,074, or 34 percent.

Election commission president Daniel Ngoy Mulunda released the early results four days after Monday's vote, after the Election Day was extended for three days to give porters time to transport ballots from the remote corners of this giant nation.

Compiling the results was chaotic. In the capital Kinshasa, sacks of ballots brought in on the backs of poll workers piled up on grass outside the counting center, many having split open. People trampled on the ballots which had spilled on the dirt path leading into the warehouse.

Mulunda released the first results after opposition candidate Vital Kamerhe called a press conference urging the commission to publish partial results for the sake of transparency.

Complicating procedures, fake results had been posted on the election commission's website, said Mulunda. Young Tshisekedi supporters also weaved between cars at downtown intersections, selling a $1 sheet showing a different set of provisional results which had their choice of president in the lead.

Congo remains on edge after days of violence which left at least 18 dead and seriously wounded 100 more, with most of the deaths caused by troops loyal to Kabila, Human Rights Watch said in Friday.

The violence peaked on Saturday when tens of thousands of people descended on Kinshasa's airport to welcome home Tshisekedi as he returned from his final campaign tour in the country's interior. In the government crackdown that followed, at least 14 people were killed, according to the report by the New York-based rights group.

Soldiers fired into the crowd, hitting a 27-year-old mother of five in the head. Among the other victims was a 22-year-old who was shot dead while walking outside a granary near the airport. On Election Day, mobs descended on poling stations. Poll workers were beaten, and vote centers were destroyed.

Government spokesman Lambert Mende denied the accusations in the report, saying the presidential guard shot in the air.

"We are in an African city. We are Africans. And nowhere ? not in (the neighborhood of) Masina, not in the mayor's office ? no one is aware of a wake, or of a funeral. No cemetery has registered a burial. Only HRW is aware of this," he said.

Analysts are concerned that there could be further bloodshed when the election results are announced, scheduled for next Tuesday.

The U.N. Security Council on Friday condemned the bloodshed and urged all candidates and their supporters to refrain from further violent acts.

Congo's enormous territory still includes sections of the bush that are controlled by rebel groups, like in the east where the brutal Lord's Resistance Army is known to be based.

In Oriental province near the town of Faradje, Human Rights Watch says the Lord's Resistance Army attacked a group of voters on their way to vote. Three men were killed, and ten women were abducted. The report says that one of the women, who was six months' pregnant, was raped. She was later released and taken to the hospital but lost her baby.

This is only the second free election in Congo's 51-year history, and the first to be organized entirely by the government instead of by the international community. The logistical challenges are casting a cloud of doubt over the vote, and three of the 11 candidates running for president have already called for the ballot to be annulled.

Source: http://us.rd.yahoo.com/dailynews/rss/africa/*http%3A//news.yahoo.com/s/ap/20111202/ap_on_re_af/af_congo_election

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Love Games Season 3 Premiere

Oxygen meddles with love once again with the season three return of the dating competition series “Love Games: Bad Girls Need Love Too,” featuring former “Bad Girls” – Judi (season seven), Kori (season six) and Sydney (season six) — as they compete and search for love from a pool of 13 eligible suitors who can [...]

Source: http://www.celebritymound.com/love-games-season-3-premiere/?utm_source=rss&utm_medium=rss&utm_campaign=love-games-season-3-premiere

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Sunday, December 4, 2011

Congo elections: Poll results, and irregularities, trickle in

Guest blogger Jason K. Stearns -- who is observing the elections in Bukavu -- provides a few results, and warns that charges of irregularities suggest the potential for violence ahead.

Results are trickling in slowly, while speculations are flying around in all possible directions. Tshisekedi's people claim that they will win 55% of the vote, while the president's people are sure of victory. It is difficult to imagine a situation in which one of the hopefuls gracefully concedes; it is easy to imagine how violent escalation could take place.?

Skip to next paragraph

I have posted some results below, all of which stem from Congolese civil society observers.

First, however, some developments. The compilation is proceeding very slowly, with only a few percent of votes in each province officially compiled. People who visit the four national compilation centers in Kinshasa report somewhat chaotic scenes, with some ballot envelopes torn and strewn about. Election commission president Ngoy Mulunda told reporters that election officials will invalidate any package that do not meet the requirements - which raised questions of what will happen with torn envelopes. In addition, he had previously been reported as saying that elections will not be repeated in areas where voters burned down polling stations, raising further question of voter disenfranchisement. The election commission is not making results known as it goes, and the media authority has banned any announcement of preliminary results in the press.?

UDPS (the opposition Union for Democracy and Social Progress party)?officials have been sending text messages around the country reporting the arrival of airplanes full of ballots after election day. Diplomats confirm that three airplanes arrived at Njili airport in Kinshasa - one on November 29, two on the morning of November 30 - from South Africa. While some sources suggest that the first plane had 20 tons of election material on it, I have not been able to confirm the freight of the second two planes. It would, of course, be strange for the government to be importing ballots to the country when voting had ended in the vast majority of areas.

In the meantime, all major observation missions have put out preliminary statements on the process. All congratulated the Congolese on elections and the election commission on rising to the huge logistical challenge. None of them passed judgment on the elections in general - that will have to wait for their final report - and only the Congolese Renosec monitors from civil society confirmed that there had been fraud, "but not enough to call into question the process." The Carter Center suggested that in 16% of cases irregularities led to a negative evaluation of voting, while the European Union provided an exhaustive list of flaws but did not suggest that this had compromised the overall process. We will have to wait for 5 days (and perhaps longer?) for a final conclusion.?
Nonetheless, some preliminary results, to be taken with care (also, these are all urban areas):

Kananga town (53,000 votes counted):
Tshisekedi 95,7%
Kabila 3,5%
Uvira (38,000)
Kabila 65%
Kamerhe 30%
Tshisekedi 5%
Butembo town (63,000)
Mbusa Nyamwisi 37%
Kamerhe: 26%
Kabila: 22%
Beni town (54,000)
Mbusa Nyamwisi 33%
Kabila 24%
Kamerhe 21%
Bukavu (103,000)
Kamerhe 66%
Kabila 34%
Kisangani (unknown number of votes counted)
Kamerhe 2%-10%
Tshisekedi 2%-20%
Kabila 20%-80%

? Jason K.Stearns blogs about the?Democratic Republic of Congo?and the Great Lakes region at?Congo Siasa.

The Christian Science Monitor has assembled a diverse group of Africa bloggers. Our guest bloggers are not employed or directed by the Monitor and the views expressed are the bloggers' own, as is responsibility for the content of their blogs. To contact us about a blogger,?click here.

The Christian Science Monitor has assembled a diverse group of Africa bloggers. Our guest bloggers are not employed or directed by the Monitor and the views expressed are the bloggers' own, as is responsibility for the content of their blogs. To contact us about a blogger, click here.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/yw_RviD3NkM/Congo-elections-Poll-results-and-irregularities-trickle-in

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Saturday, December 3, 2011

Walmart Launches Shopycat, A Social Gift Finder Built On Top Of Facebook

ShopycatRetailing giant Walmart is launching its first-ever social gifting platform tonight, dubbed "Shopycat." The service, previously in beta, is initially available as a Facebook application where it will also be promoted to the nearly 11 million Facebook users who have "liked" Walmart's fan page. The app, which suggests gifts for friends based on their Facebook use, was built with technology Walmart acquired from social media startup Kosmix (now @WalmartLabs) earlier this year. And here's the interesting part: the new app won't just point you to pages on Walmart.com for its gift recommendations. It also recommends products from nearly two dozen other retailers, including Barnes & Noble, ThinkGeek, RedEnvelope, NBC Universal, Hot Topic and more. (Just not, of course, Amazon).

Source: http://feedproxy.google.com/~r/Techcrunch/~3/8eop2G0qLio/

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PROMISES, PROMISES: Candidates shield records (AP)

WASHINGTON ? In the final weeks of Mitt Romney's term as Massachusetts governor, a small team of aides combed through statehouse filing cabinets. They filled more than 630 cartons with papers destined for the state archives as the primary documentary legacy of his administration. One floor, though, was almost completely off limits to them: Romney's inner sanctum, his third-floor office.

The former legislative affairs director who headed the archiving effort, John O'Keefe, recalls that his team was given a stack of Romney's public schedules over four years and a limited variety of other documents from the governor's executive office, but not much else. "We were told we were not in charge of archiving the third floor," he says.

The mystery deepened recently when the chief legal counsel for Romney's Democratic successor, Gov. Deval Patrick, said that just before Patrick took office, material on a state government web server that housed Romney's emails was erased. Top Romney aides also bought and removed their state-issued computer hard drives, and remaining leased computers were replaced. Romney said he followed the law in authorizing the purge, and his campaign aides said their actions were based on a 1997 Massachusetts court ruling that all governors' records are private.

Romney's selective policy toward public access and preservation of his executive records raises stark questions about how transparent his administration would be if he were to become president. He's not alone. Other leading candidates for the presidency ? incumbent Barack Obama and Texas Gov. Rick Perry ? have touted their commitment to transparency, but their administrations also have been selective at times in the records they disclose. They have limited, stalled or denied access when it suited their purposes.

"What I wish Americans could expect is a politician who talked a good game and walked a good game, too," said Ken Bunting, executive director of the nonpartisan National Freedom of Information Coalition. "The reality is everybody gives lip service to transparency and accountability."

Romney's submission of paper documents to the Massachusetts archives was made "in the interest of transparency and to help provide a record of his time in office," said Eric Fehrnstrom, a senior campaign adviser. But the holdings in the archives are far from comprehensive. An Associated Press reporter sent from Washington earlier this fall spent a week examining the Romney archives, but did not find paper copies of any emails to or from Romney or any internal calendars or in-house memos ? all commonly used by governors. There are no state archives records accounting for what happened to those materials.

The growing use by government agencies and political campaigns of new channels of electronic communication, including text messages, online videos and social media services, has opened new dimensions in the availability of public records. But presidential candidates haven't been especially transparent.

"There's the potential for a lot more raw information than in the past as emails and other electronic communications replace phone and face-to-face conversations," said Peter Scheer, executive director of the First Amendment Coalition, a nonprofit public interest group. "The problem is we're seeing officials and governments moving more and more to shield those materials from public access."

Only about one-quarter of the 630 cartons of Romney paper records are available for inspection at the Massachusetts archives. State legal officials have yet to say whether the 1997 court ruling allows access to the other material. Even if they do, Assistant State Archivist Michael Comeau said, staff shortages and time-consuming redaction checks could extend delays close to the 2012 election. More than 75 cartons examined by the AP revealed staff and legislative documents but no internal materials written to or from Romney himself ? except for ceremonial bill-signing and official letters.

As governor, Romney's careful line on providing records was based on a 1997 Massachusetts Supreme Judicial Court ruling that "the governor is not explicitly included" among other state officials and agencies covered by the state's Public Records Law, which generally requires agencies to submit to records requests. Other governors since 1997 have interpreted the ruling similarly.

The AP submitted detailed questions to Romney about how his administration handled public records when he was governor, but the campaign responded with only a brief statement: "The governor's office in Massachusetts is not subject to the state's public records law. As a legal matter, it is not required to disclose any documents." Fehrnstrom, who was Romney's chief spokesman during that era, said the Romney campaign does not possess any remaining gubernatorial records outside of the Massachusetts archives.

After The Boston Globe first reported that his aides had purged electronic files, Romney said the deleted materials might have contained confidential medical, judicial or personnel records. Still, when Romney's archive team found confidential files at the end of his administration, they separated those materials from thousands of other documents that were turned over to the archives. O'Keefe, now city manager in Manchester, Vt., recalled that anything that appeared "confidential in nature" was turned over to a private vendor for shredding.

Suggesting that Romney's Massachusetts administration "deliberately sought to delete public records" in advance of his 2007 presidential run, the Democratic National Committee has pressed three separate Massachusetts public records requests for more background on the purge. Romney's campaign has responded with its own request to Patrick's office asking for any evidence of collaboration between his staff and Obama re-election officials.

Gavi Wolfe, a legal counsel for the Boston office of the American Civil Liberties Union, said Romney's authorization of the purging of third-floor electronic files set an "alarming" precedent: "I would be concerned about the chief executive wanting to shield the actions of his administration from public scrutiny." Romney said during a New Hampshire campaign stop that if elected, his presidential administration "would do what's required by the law and then some."

In three years in the White House, Obama set an even more ambitious standard, committing publicly to improving transparency and setting clear goals for federal agencies to respond more quickly and expansively to public records requests.

Obama signed an executive order on his first day in office in 2009, directing federal officials to make good on his detailed commitment to broaden accountability. His directive led to the opening of White House visitor logs and plans to improve responses to records requests, whistleblower protections and declassification of outdated secret documents.

But many of Obama's broad commitments have not been met. In the face of criticism, the Justice Department abandoned a proposal that would have allowed officials to pretend that some government files didn't exist when people asked to see them. And the government completely turned down records in one-third of all requests in 2010 ? even censoring 194 pages of internal emails about Obama's Open Government directive.

The White House and Energy Department have been hesitant and selective turning over records related to the GOP-led congressional investigation of Solyndra, the failed California solar panel company. The AP pressed three separate appeals for records in September, but Energy Department officials said they would take months because of the number of documents and requests to read them. In early October, as Congress threatened to issue subpoenas, White House officials quickly provided reporters with thousands of pages and DVDs filled with hundreds of emails.

White House officials would not comment on the sudden shift, but campaign spokesman Ben LaBolt said, "The president and this administration are changing the ways Washington works in terms of transparency."

In Texas, Perry has made similar claims, pointing to broad swaths of electronic data that his administration has made available online ? from state agency expenditures to death certificates. But Perry's administration has also blocked viewing of expenditures for his security guards when he travels, even though much of that travel has been subsidized by campaign funds or by private business executives. He also barred access to his reviews of death penalty cases and to his private calendars, even though his predecessor, former President George W. Bush, had made both available when he was governor.

"The people of America aren't seeing the real Rick Perry," said Keith Elkins, executive director of the Freedom of Information Foundation of Texas. "They may get a glimpse of him on the campaign trail, but the real record has been hidden and carefully parceled out."

___

Associated Press writers Brett J. Blackledge, Matthew Daly and Jack Gillum contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/gop/*http%3A//news.yahoo.com/s/ap/20111130/ap_on_el_pr/us_campaigns_transparency

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